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1

Radical-scavenging effects of Aloe arborescens Miller on prevention of pancreatic islet B-cell destruction in rats

Hidehiko Beppu, Takaaki Koike, Kan Shimpo, Takeshi Chihara, Motoyuki Hoshino, Chikako Ida, Hiroshi Kuzuya

Journal:

Journal of Ethnopharmacology

Year:

2003

Language:

english

File:

PDF, 288 KB

english, 2003

2

A novel model of occlusive thrombus formation in mice

Sasaki, Takeshi, Kuzuya, Masafumi, Cheng, Xian-Wu, Nakamura, Kae, Tamaya-Mori, Norika, Maeda, Keiko, Kanda, Shigeru, Koike, Teruhiko, Sato, Kohji, Iguchi, Akihisa

Journal:

Laboratory Investigation

Year:

2004

Language:

english

File:

PDF, 338 KB

english, 2004

3

Chemopreventive effects of Aloe arborescens on N-nitrosobis(2-oxopropyl)amine-induced pancreatic carcinogenesis in hamsters

Fumio Furukawa, Akiyoshi Nishikawa, Takeshi Chihara, Kan Shimpo, Hidehiko Beppu, Hiroshi Kuzuya, In-Seon Lee, Masao Hirose

Journal:

Year:

2002

Language:

english

File:

PDF, 89 KB

english, 2002

4

Determination of aloenin, barbaloin and isobarbaloin in Aloe species by micellar electrokinetic chromatography

Hiroshi Kuzuya, Ikuko Tamai, Hidehiko Beppu, Kan Shimpo, Takeshi Chihara

Journal:

Journal of Chromatography B: Biomedical Sciences and Applications

Year:

2001

Language:

english

File:

PDF, 455 KB

english, 2001

5

Antidiabetic effects of dietary administration of Aloe arborescens Miller components on multiple low-dose streptozotocin-induced diabetes in mice: Investigation on hypoglycemic action and systemic absorption dynamics of aloe components

Hidehiko Beppu, Kan Shimpo, Takeshi Chihara, Takaaki Kaneko, Ikuko Tamai, Sachiyo Yamaji, Sayaka Ozaki, Hiroshi Kuzuya, Shigeru Sonoda

Journal:

Journal of Ethnopharmacology

Year:

2006

Language:

english

File:

PDF, 835 KB

english, 2006

6

Family histroy of diabetic patients in Japan

Ryoko Hagura, Ayako Matsuda, Takeshi Kuzuya, Hideyo Yoshinaga, Kinori Kosaka

Journal:

Diabetes Research and Clinical Practice

Year:

1994

Language:

english

File:

PDF, 502 KB

english, 1994

7

Primary squamous cell carcinoma of the thyroid associated with marked leukocytosis and hypercalcemia

Dr. Koshi Saito, Yasuko Kuratomi, Kunihiro Yamamoto, Toshikazu Saito, Takeshi Kuzuya, Sho Yoshida, Shin-Ichi Moriyama, Atsushi Takahashi

Journal:

Year:

1981

Language:

english

File:

PDF, 447 KB

english, 1981

8

Osteoarthritic change is delayed in a Ctsk-knockout mouse model of osteoarthritis

Eiji Kozawa, Yoshihiro Nishida, Xian Wu Cheng, Hiroshi Urakawa, Eisuke Arai, Naohisa Futamura, Guo-Ping Shi, Masafumi Kuzuya, Lina Hu, Takeshi Sasaki, Naoki Ishiguro

Journal:

Arthritis & Rheumatism

Year:

2012

Language:

english

File:

PDF, 1.29 MB

english, 2012

9

Presenilin 1 is involved in the maturation of β-site amyloid precursor protein-cleaving enzyme 1 (BACE1)

Akira Kuzuya, Kengo Uemura, Naoyuki Kitagawa, Nobuhisa Aoyagi, Takeshi Kihara, Haruaki Ninomiya, Shoichi Ishiura, Ryosuke Takahashi, Shun Shimohama

Journal:

Journal of Neuroscience Research

Year:

2007

Language:

english

File:

PDF, 927 KB

english, 2007

10

Clinical assessment by MRI for patients with Stage II cervical carcinoma treated by radiation alone in multicenter analysis: are all patients with Stage II disease suitable candidates for chemoradiotherapy?

Takeshi Kodaira, Nobukazu Fuwa, Minoru Kamata, Kazuhisa Furutani, Kazuo Kuzuya, Kazuhiko Ogawa, Takafumi Toita, Masahiro Sasaoka, Yoshihito Nomoto

Journal:

International Journal of Radiation Oncology*Biology*Physics

Year:

2002

Language:

english

File:

PDF, 118 KB

english, 2002

11

Inhibition of azoxymethane-induced aberrant crypt foci formation in rat colorectum by whole leaf Aloe arborescens Miller var. natalensis berger

Kan Shimpo, Takeshi Chihara, Hidehiko Beppu, Chikako Ida, Takaaki Kaneko, Toshiharu Nagatsu, Hiroshi Kuzuya

Journal:

Phytotherapy Research

Year:

2001

Language:

english

File:

PDF, 118 KB

english, 2001

12

Aloe arborescens extract inhibits TPA-induced ear oedema, putrescine increase and tumour promotion in mouse skin

Kan Shimpo, Chikako Ida, Takeshi Chihara, Hidehiko Beppu, Takaaki Kaneko, Hiroshi Kuzuya

Journal:

Phytotherapy Research

Year:

2002

Language:

english

File:

PDF, 70 KB

english, 2002

13

Studies on the mechanism of xylitol-induced insulin secretion in dogs

Takeshi Kuzuya, Yasunori Kanazawa

Journal:

Year:

1969

Language:

english

File:

PDF, 891 KB

english, 1969

14

Some comments on the diagnosis of diabetes mellitus

Journal:

Diabetology International

Year:

2010

Language:

english

File:

PDF, 108 KB

english, 2010

15

Comparison of prognostic value of MRI and FIGO stage among patients with cervical carcinoma treated with radiotherapy

Takeshi Kodaira, Nobukazu Fuwa, Takafumi Toita, Yoshihito Nomoto, Kazuo Kuzuya, Hiroyuki Tachibana, Kazuhisa Furutani, Kazuhiko Ogawa

Journal:

International Journal of Radiation Oncology*Biology*Physics

Year:

2003

Language:

english

File:

PDF, 111 KB

english, 2003

16

N-cadherin enhances APP dimerization at the extracellular domain and modulates Aβ production

Megumi Asada-Utsugi, Kengo Uemura, Yasuha Noda, Akira Kuzuya, Masato Maesako, Koichi Ando, Masakazu Kubota, Kiwamu Watanabe, Makio Takahashi, Takeshi Kihara, Shun Shimohama, Ryosuke Takahashi, Oksana

Journal:

Journal of Neurochemistry

Year:

2011

Language:

english

File:

PDF, 419 KB

english, 2011

17

Effect of vasopressin antagonist on water excretion in inferior vena cava constriction

Ishikawa, San-e, Saito, Toshikazu, Okada, Koji, Tsutsui, Kumiko, Kuzuya, Takeshi

Journal:

Kidney International

Year:

1986

Language:

english

File:

PDF, 606 KB

english, 1986

18

Reversal of somatostatin inhibition of AVP-induced cAMP by pertussis toxin

Ishikawa, San-e, Saito, Toshikazu, Kuzuya, Takeshi

Journal:

Kidney International

Year:

1988

Language:

english

File:

PDF, 645 KB

english, 1988

19

Retroperitoneal hemangiopericytoma associated with hypoglycemia: Report of a case

Yoshikazu Yasuda, Kogoro Kasahara, Sumio Tenmoku, Chikaharu Yabe, Michio Miyapa, Yasuhiko Morioka, Yoshikazu Sakamoto, Takeshi Kuzuya, Kazushi Takeda, Tetsushi Atsumi, Hideo Shimizu, Saburo Matsumoto

Journal:

Year:

1979

Language:

english

File:

PDF, 881 KB

english, 1979

20

Studies on the components of Aloe arborescens from Japan—monthly variation and differences due to part and position of the leaf

Hidehiko Beppu, Kaoru Kawai, Kan Shimpo, Takeshi Chihara, Ikuko Tamai, Chikako Ida, Mayumi Ueda, Hiroshi Kuzuya

Journal:

Biochemical Systematics and Ecology

Year:

2004

Language:

english

File:

PDF, 199 KB

english, 2004

21

The effect of epinephrine on immunoreactive insulin levels in man

Daniel Porte Jr, Alan L. Graber, Takeshi Kuzuya, Robert H. Williams

Journal:

Year:

1996

Language:

english

File:

PDF, 124 KB

english, 1996

22

HYPERMINERALOCORTICISM WITHOUT ELEVATION OF PLASMA ALDOSTERONE: DEOXYCORTICOSTERONE-PRODUCING ADRENAL ADENOMA AND HYPERPLASIA

SAN-E ISHIKAWA, TOSHIKAZU SAITO, KENZO KANEKO, KOJI OKADA, SHUICHI FUKUDA, TAKESHI KUZUYA

Journal:

Clinical Endocrinology

Year:

1988

Language:

english

File:

PDF, 650 KB

english, 1988

23

Gain of function by phosphorylation in Presenilin 1-mediated regulation of insulin signaling

Masato Maesako, Kengo Uemura, Akira Kuzuya, Kazuki Sasaki, Megumi Asada, Kiwamu Watanabe, Koichi Ando, Masakazu Kubota, Haruhiko Akiyama, Ryosuke Takahashi, Takeshi Kihara, Shun Shimohama, Ayae Kinosh

Journal:

Journal of Neurochemistry

Year:

2012

Language:

english

File:

PDF, 454 KB

english, 2012

24

Atrial natriuretic factor increases cyclic GMP and inhibits cyclic AMP in rat renal papillary collecting tubule cells in culture

San-e Ishikawa, Toshikazu Saito, Koji Okada, Takeshi Kuzuya, Kenji Kangawa, Hisayuki Matsuo

Journal:

Biochemical and Biophysical Research Communications

Year:

1985

Language:

english

File:

PDF, 387 KB

english, 1985

25

A simple and sensitive assay for dopamine-β-hydroxylase activity by dual-wavelength spectrophotometry

Takeshi Kato, Hiroshi Kuzuya, Toshiharu Nagatsu

Journal:

Biochemical Medicine

Year:

1974

Language:

english

File:

PDF, 519 KB

english, 1974

26

Activity-dependent regulation of β-catenin via ε-cleavage of N-cadherin

Kengo Uemura, Takeshi Kihara, Akira Kuzuya, Katsuya Okawa, Takaaki Nishimoto, Haruhiko Bito, Haruaki Ninomiya, Hachiro Sugimoto, Ayae Kinoshita, Shun Shimohama

Journal:

Biochemical and Biophysical Research Communications

Year:

2006

Language:

english

File:

PDF, 1.07 MB

english, 2006

27

PI3K inhibition causes the accumulation of ubiquitinated presenilin 1 without affecting the proteasome activity

Nobuhisa Aoyagi, Kengo Uemura, Akira Kuzuya, Takeshi Kihara, Jun Kawamata, Shun Shimohama, Ayae Kinoshita, Ryosuke Takahashi

Journal:

Biochemical and Biophysical Research Communications

Year:

2010

Language:

english

File:

PDF, 505 KB

english, 2010

28

Prevention of type 2 diabetes by lifestyle intervention: a Japanese trial in IGT males

Kinori Kosaka, Mitsuihiko Noda, Takeshi Kuzuya

Journal:

Diabetes Research and Clinical Practice

Year:

2005

Language:

english

File:

PDF, 200 KB

english, 2005

29

Characterization of sequential N-cadherin cleavage by ADAM10 and PS1

Kengo Uemura, Takeshi Kihara, Akira Kuzuya, Katsuya Okawa, Takaaki Nishimoto, Haruaki Ninomiya, Hachiro Sugimoto, Ayae Kinoshita, Shun Shimohama

Journal:

Neuroscience Letters

Year:

2006

Language:

english

File:

PDF, 398 KB

english, 2006

30

Insulin regulates Presenilin 1 localization via PI3K/Akt signaling

Masato Maesako, Kengo Uemura, Masakazu Kubota, Koichi Ando, Akira Kuzuya, Megumi Asada, Takeshi Kihara, Ayae Kinoshita

Journal:

Neuroscience Letters

Year:

2010

Language:

english

File:

PDF, 318 KB

english, 2010

31

Functional regulation of Presenilin1 via insulin signaling

Masato Maesako, Kengo Uemura, Masakazu Kubota, Akira Kuzuya, Koichi Ando, Takeshi Ikeuchi, Megumi Asada, Ayae Kinoshita

Journal:

Neuroscience Research

Year:

2009

Language:

english

File:

PDF, 86 KB

english, 2009

32

Environmental enrichment ameliorated high-fat diet-induced Aβ deposition and memory deficit in APP transgenic mice

Masato Maesako, Kengo Uemura, Masakazu Kubota, Akira Kuzuya, Kazuki Sasaki, Megumi Asada, Kiwamu Watanabe, Naoko Hayashida, Masafumi Ihara, Hidefumi Ito, Shun Shimohama, Takeshi Kihara, Ayae Kinoshita

Journal:

Neurobiology of Aging

Year:

2012

Language:

english

File:

PDF, 2.64 MB

english, 2012

33

Increased Expression of Elastolytic Cysteine Proteases, Cathepsins S and K, in the Neointima of Balloon-Injured Rat Carotid Arteries

Xian Wu Cheng, Masafumi Kuzuya, Takeshi Sasaki, Koji Arakawa, Shigeru Kanda, Daigo Sumi, Teruhiko Koike, Keiko Maeda, Norika Tamaya-Mori, Guo-Ping Shi, Noboru Saito, Akihisa Iguchi

Journal:

The American Journal of Pathology

Year:

2004

Language:

english

File:

PDF, 1007 KB

english, 2004

34

Epigallocatechin-3-gallate binding to MMP-2 inhibits gelatinolytic activity without influencing the attachment to extracellular matrix proteins but enhances MMP-2 binding to TIMP-2

Xian Wu Cheng, Masafumi Kuzuya, Shigeru Kanda, Keiko Maeda, Takeshi Sasaki, Qiu Lan Wang, Norika Tamaya-Mori, Tami Shibata, Akihisa Iguchi

Journal:

Archives of Biochemistry and Biophysics

Year:

2003

Language:

english

File:

PDF, 324 KB

english, 2003

35

Additive effect of islet amyloid polypeptide (IAPP/amylin) and insulin on 2-deoxyglucose uptake in mouse pancreatic acini

Yasuhiko Iwamoto, Gen Inooka, Nobuko Sakuma, Ikuo Shiraishi, Shinobu Kumakura, Takuya Awata, Takeshi Kuzuya

Journal:

Biochemical and Biophysical Research Communications

Year:

1991

Language:

english

File:

PDF, 281 KB

english, 1991

36

Importance of standardization of hemoglobin A1c in the analysis of factors that predict hemoglobin A1c levels in non-diabetic residents of three distinct areas of Japan

Yoshihiko Takahashi, Mitsuhiko Noda, Shoichiro Tsugane, Satoshi Kimura, Yasuo Akanuma, Takeshi Kuzuya, Yasuo Ohashi, Takashi Kadowaki

Journal:

Diabetes Research and Clinical Practice

Year:

2001

Language:

english

File:

PDF, 97 KB

english, 2001

37

Report of the Committee on the classification and diagnostic criteria of diabetes mellitus

Takeshi Kuzuya, Shoichi Nakagawa, Jo Satoh, Yasunori Kanazawa, Yasuhiko Iwamoto, Masashi Kobayashi, Kisihio Nanjo, Akira Sasaki, Yutaka Seino, Chikako Ito, Kenji Shima, Kyohei Nonaka, Takashi Kadowaki

Journal:

Diabetes Research and Clinical Practice

Year:

2002

Language:

english

File:

PDF, 205 KB

english, 2002

38

Clinical features of diabetes mellitus with the mitochondrial DNA 3243 (A–G) mutation in Japanese: Maternal inheritance and mitochondria-related complications

Susumu Suzuki, Yoshitomo Oka, Takashi Kadowaki, Azuma Kanatsuka, Takeshi Kuzuya, Masashi Kobayashi, Tokio Sanke, Yutaka Seino, Kishio Nanjo

Journal:

Diabetes Research and Clinical Practice

Year:

2003

Language:

english

File:

PDF, 157 KB

english, 2003

39

Baseline factors affecting the efficacy of troglitazone on plasma glucose in Japanese patients with non-insulin-dependent diabetes mellitus

Takeshi Kuzuya, Kinori Kosaka, Yasuo Akanuma, Yukio Shigeta, Toshio Kaneko

Journal:

Diabetes Research and Clinical Practice

Year:

1998

Language:

english

File:

PDF, 132 KB

english, 1998

40

Localization of Cysteine Protease, Cathepsin S, to the Surface of Vascular Smooth Muscle Cells by Association with Integrin ανβ3

Xian Wu Cheng, Masafumi Kuzuya, Kae Nakamura, Qun Di, Zexuan Liu, Takeshi Sasaki, Shigeru Kanda, Hai Jin, Guo-Ping Shi, Toyoaki Murohara, Mitsuhiro Yokota, Akihisa Iguchi

Journal:

The American Journal of Pathology

Year:

2006

Language:

english

File:

PDF, 1.00 MB

english, 2006

41

Superoxide-Dependent Cathepsin Activation Is Associated with Hypertensive Myocardial Remodeling and Represents a Target for Angiotensin II Type 1 Receptor Blocker Treatment

Xian Wu Cheng, Toyoaki Murohara, Masafumi Kuzuya, Hideo Izawa, Takeshi Sasaki, Koji Obata, Kohzo Nagata, Takao Nishizawa, Masakazu Kobayashi, Takashi Yamada, Weon Kim, Kohji Sato, Guo-Ping Shi, Kenji

Journal:

The American Journal of Pathology

Year:

2008

Language:

english

File:

PDF, 2.13 MB

english, 2008

42

Stimulation of pyruvate dehydrogenase activity by insulin-dextran complex in mouse adipose tissue

Yoshikazu Sakamoto, Takeshi Kuzuya

Journal:

Biochemical and Biophysical Research Communications

Year:

1979

Language:

english

File:

PDF, 409 KB

english, 1979

43

Statin prevents plaque disruption in apoE-knockout mouse model through pleiotropic effect on acute inflammation

Kae Nakamura, Takeshi Sasaki, Xian Wu Cheng, Akihisa Iguchi, Kohji Sato, Masafumi Kuzuya

Journal:

Atherosclerosis

Year:

2009

Language:

english

File:

PDF, 1.22 MB

english, 2009

44

A response to the letter regarding the pleiotropic effects of fluvastatin on acute inflammatory response and the role of MMP-9 in plaque destabilization and intraplaque hemorrhage

Kae Nakamura, Takeshi Sasaki, Xian Wu Cheng, Masafumi Kuzuya

Journal:

Atherosclerosis

Year:

2009

Language:

english

File:

PDF, 94 KB

english, 2009

45

AT1 blockade attenuates atherosclerotic plaque destabilization accompanied by the suppression of cathepsin S activity in apoE-deficient mice

Takeshi Sasaki, Masafumi Kuzuya, Kae Nakamura, Xian Wu Cheng, Taiju Hayashi, Haizhen Song, Lina Hu, Kenji Okumura, Toyoaki Murohara, Akihisa Iguchi, Kohji Sato

Journal:

Atherosclerosis

Year:

2010

Language:

english

File:

PDF, 1.21 MB

english, 2010

46

Imaging mass spectrometry-based histopathologic examination of atherosclerotic lesions

Nobuhiro Zaima, Takeshi Sasaki, Hiroki Tanaka, Xian Wu Cheng, Kenji Onoue, Takahiro Hayasaka, Naoko Goto-Inoue, Hirofumi Enomoto, Naoki Unno, Masafumi Kuzuya, Mitsutoshi Setou

Journal:

Atherosclerosis

Year:

2011

Language:

english

File:

PDF, 1.16 MB

english, 2011

47

Immunological reactivity of insulin to sepharose coupled with insulin-antibody—Its use for the extraction of insulin from serum

Yasuo Akanuma, Takeshi Kuzuya, Masaki Hayashi, Takehiko Ide, Nobusada Kuzuya

Journal:

Biochemical and Biophysical Research Communications

Year:

1970

Language:

english

File:

PDF, 295 KB

english, 1970

48

The plasma insulin “inhibitor” and immunoprecipitation assay

Takeshi Kuzuya, Ellis Samols

Journal:

Year:

1964

Language:

english

File:

PDF, 229 KB

english, 1964

49

Plasma insulin response to intravenously administered xylitol in dogs

Takeshi Kuzuya, Yasunori Kanazawa, Kinori Kosaka

Journal:

Year:

1966

Language:

english

File:

PDF, 268 KB

english, 1966

50

Plasma insulin response to intravenous administration of tetragastrin (C-terminal tetrapeptide amide of gastrin) in man

Masatoshi Kikuchi, Takeshi Kuzuya, Takehiko Ide

Journal:

Year:

1971

Language:

english

File:

PDF, 823 KB

english, 1971

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